John Wayne Casserole (2024)

John Wayne Casserole is an easy ground beef casserole recipe with a biscuit base and loaded with diced tomatoes, corn, taco seasoning, cream cheese, mozzarella and cheddar.

John Wayne Casserole is a delicious ground beef and biscuit casserole made with Bisquick.

This simple and flavourful casserole is sure to please the whole family.

This ground beef casserole recipe takes about an hour from start to finish and serves six people.

Ingredients You’ll Need for John Wayne Casserole

• 1 lb lean ground beef
• 2 cups water
• 1 oz taco seasoning
• 1 cup diced yellow onion
• 20 oz Rotel diced tomatoes and green chilies, drained
• 12 oz canned corn, drained

Biscuit Layer

• 3 cups Bisquick mix

Topping

• 7.5 oz Philadelphia whipped chive cream cheese
• 1/2 cup mayo
• 1 tbsp garlic powder
• 1/2 tsp salt
• 2 cups shredded mozzarella and cheddar cheese blend

Printable Recipe Card with a Full List of Ingredients and Instructions is Located at the Bottom of the Post.

Be sure to read through the entire post so that you don’t miss out on any important tips and tricks!

Step by Step Instructions for Making John Wayne Casserole

I crumbled the ground beef well as it cooked.

Then I added some water and taco seasoning to the pan with the ground beef.

After four minutes, I added some diced onions, two cans of Rotel diced tomatoes and green chilies and some canned corn to the pan with the ground beef.

Then I poured some Bisquick mix into a large mixing bowl.

Then I stirred until a sticky dough formed.

Then I scooped the ground beef mixture on top of the dough and spread it out evenly.

Then I added some garlic powder and salt to the bowl.

I used an electric mixer to cream together the mayo and cream cheese until smooth.

I sprinkled some shredded mozzarella and cheddar cheese on top of the cream cheese mixture.

After 40 minutes I removed the casserole from the oven and left it to sit for a few minutes before slicing and serving.

This cheesy ground beef and biscuit casserole is the perfect comfort food.

The Rotel and taco seasoning give this dish a bit of a kick but it’s not overly spicy.

If you are looking for a tasty casserole recipe using ground beef, then you need to try this John Wayne Casserole!

Just take me to the Recipe –> Click HERE <

How should I store my John Wayne Casserole?

Store any leftovers in an airtight container in the refrigerator for up to 3 days. For longer storage freeze for up to 3 months. Reheat thoroughly before serving.

What substitutions could I make in John Wayne casserole?

If you need to make substitutions in a John Wayne casserole, you have several options depending on your dietary preferences or ingredient availability. Here are some common substitutions you can consider:

1. Ground Meat: The original recipe calls for ground beef. However, you can substitute it with ground turkey, chicken, pork, or a plant-based alternative like crumbled tofu or textured vegetable protein (TVP).
2. Cheese: If you’re looking for a healthier or dairy-free option, you can use a plant-based cheese alternative or omit the cheese altogether. Alternatively, you can experiment with different types of cheese such as Havarti, Swiss or Monterey Jack to suit your taste.
3. Cream Cheese and Mayo: Instead of cream cheese and mayo you can use sour cream, plain Greek yogurt or dairy-free yogurt as a substitute. They provide a similar creamy tang to the dish.
4. Vegetables: Feel free to add or swap vegetables based on your preferences. You can include diced bell peppers, peas, carrots, zucchini, or any other vegetables you enjoy.

Remember, substitutions may alter the taste and texture of the casserole slightly, so it’s best to experiment and find combinations that you enjoy.

What should I serve with John Wayne Casserole?

John Wayne casserole is a hearty dish on its own, but if you’re looking to serve it with some complementary sides, here are a few suggestions:

1. Salad: A fresh green salad with a light dressing can help balance the richness of the casserole. Consider a simple garden salad with mixed greens, cherry tomatoes, cucumbers, and your favorite dressing.
2. Cornbread: Cornbread pairs wonderfully with the flavors of a John Wayne casserole. Serve it warm with butter or honey on the side for a delightful combination of flavors.
3. Steamed Vegetables: Lightly steamed vegetables like broccoli, cauliflower, or green beans can add a healthy and vibrant element to the meal. Season them with a touch of salt and pepper or a drizzle of lemon juice.
4. Baked Beans: Another popular side dish to serve with casseroles is baked beans. The sweet and savory flavors of baked beans can complement the flavors of the casserole nicely.

Yield: 6 people

Prep Time: 30 minutes

Cook Time: 40 minutes

Total Time: 1 hour 10 minutes

John Wayne Casserole is an easy ground beef casserole recipe with a biscuit base and loaded with diced tomatoes, corn, taco seasoning, cream cheese, mozzarella and cheddar.

Ingredients

• 1 lb lean ground beef
• 1 cup water
• 1 oz taco seasoning
• 1 cup diced yellow onion
• 20 oz Rotel diced tomatoes and green chilies, drained
• 12 oz canned corn, drained

Biscuit Layer

• 3 cups Bisquick mix
• 1 cup water

Topping

• 7.5 oz Philadelphia whipped chive cream cheese
• 1/2 cup mayo
• 1 tbsp garlic powder
• 1/2 tsp salt
• 2 cups shredded mozzarella and cheddar cheese blend

Instructions

1. Preheat oven to 325F.
2. Dump ground beef into a large saute pan over medium-high heat.
3. Crumble ground beef well as it cooks.
4. Once the ground beef is fully cooked, drain the grease from the pan.
5. Add the water and taco seasoning to the pan with the ground beef.
6. Stir well and leave to simmer over medium-high heat for 4 minutes.
7. Add the diced onions, Rotel and corn to the pan.
8. Stir well and reduce the heat to low.
9. Dump the Bisquick mix and water into a mixing bowl.
10. Stir until a sticky dough forms.
11. Dump the dough into the bottom of a greased 9 x 13 inch baking dish and spread it out evenly.
12. Dump the ground beef mixture on top of the dough and spread it out evenly.
13. Dump the cream cheese, mayo, onion powder and salt into a mixing bowl and cream together with an electric mixer until smooth.
14. Spoon the cream cheese mixture on top of the ground beef mixture in the baking dish and spread it out as evenly as possible.
15. Sprinkle the shredded mozzarella and cheddar cheese on top.
16. Place the dish in the oven and bake for 40 minutes.
17. After 40 minutes remove the casserole from the oven and allow it to sit for a few minutes before slicing and serving.
18. Enjoy!

Recommended Products

As an Amazon Associate and member of other affiliate programs, I earn from qualifying purchases.

• 

  Ro-Tel Diced Tomatoes & Green Chilies, 10 Oz

• 

  Kraft Natural Pizza Style Mozzarella and Cheddar Shredded Cheese (8 oz Pouch)

• 

  Philadelphia Chive Whipped Cream Cheese Spread, 7.5 oz Tub

• 

  Bisquick Original Pancake and Baking Mix (96 oz. box) (pack of 2)

• 

  Black+Decker MX600T Helix Performance Premium Hand, 5-Speed Mixer, Teal

• 

  Old El Paso Taco Seasoning Mix, Original, 1 oz

Nutrition Information:

Yield: 6Serving Size: 1
Amount Per Serving:Calories: 451Total Fat: 30gSaturated Fat: 10gTrans Fat: 1gUnsaturated Fat: 18gCholesterol: 96mgSodium: 660mgCarbohydrates: 17gFiber: 2gSugar: 5gProtein: 29g

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